Building an Internal QC Program for POCT¶
A rigorous internal QC program is what separates trustworthy POCT results from unverified numbers. This page explains how to build one around the Migibio FIA680/FIA880 platform.
Why Internal QC Matters¶
Quantitative results are only as good as the system producing them. Internal QC catches drift before it affects a patient result — not after.
The Daily QC Routine¶
| Step | Frequency | Purpose |
|---|---|---|
| QC cartridge verification | Daily | Confirm the analyzer reads the expected control value |
| Lot-change verification | Per new lot | Confirm the new curve loads correctly |
| Documentation | Every run | Audit trail |
Document Everything¶
A QC log should record:
- Date, operator, analyzer.
- QC cartridge lot + result.
- Any deviation and corrective action.
If it is not documented, it did not happen — a principle that holds for accreditation and for defending a result.
Handling QC Failures¶
| Situation | Action |
|---|---|
| QC result out of range | Do not run patient samples; troubleshoot |
| Repeated failure | Clean optical path; contact support |
| New lot fails | Verify curve loaded; check lot integrity |
The QC Hierarchy¶
Internal QC is the foundation; external proficiency (EQA) validates it against other laboratories.
FAQ¶
How often should I run QC? Daily (or per IFU), plus at each lot change. Higher-risk settings may warrant more frequent QC.
What do I do if QC fails? Stop patient testing, troubleshoot (clean/verify), and document the corrective action.
For the compliance framework, see Quality Control & Compliance.
Authored by: Migibio Clinical & Scientific Affairs, Guangzhou Magic Biotech Co., Ltd.
Reviewed by: Migibio R&D Quality Committee
Last updated: 2026-08-13
Disclosure: Migibio (Guangzhou Magic Biotech Co., Ltd.) is the manufacturer of the FIA680/FIA880 analyzers and FICT reagents referenced in this content. See our Editorial & Review Policy.